WebDec 4, 2024 · Plants do not have CTCF, and their genes often do not require distal regulatory elements. Hence, plants are unlikely to have mammalian-type TAD. Our … WebAug 1, 2024 · CTCF, the so-called CCCTC-binding factor, is initially found to be a transcription repressor or corepressor in chickens (Baniahmad et al., 1990; Lobanenkov et al., 1990).The human CTCF gene contains 12 exons (Fig. 1 A) and encodes a polypeptide of 727 amino acid residues (Fig. 1 B). The encoded CTCF protein contains 11 tandem …
CTCF: a Swiss-army knife for genome organization and ... - PubMed
WebCTCF is a nuclear protein initially discovered for its role in enhancer-promoter insulation. It has been shown to play a role in genome architecture and in fact, its DNA binding sites are enriched at the borders of chromatin domains. Recently, we showed that depletion of CTCF impairs the DNA damage response to ionizing radiation. To investigate the relationship … WebThe results from CTCF quantification of immunolocalization of total glutathione indicated decreased deposition of glutathione near the apoplasts of infected cells in Col-0 and rbohD plants and increased deposition in rbohF and rbohD/F plants inoculated with virus. This suggests that modulation of cellular and apoplastic glutathione could have ... blue arbor tesi new bern
CTCF: an architectural protein bridging genome topology …
WebA topologically associating domain (TAD) is a self-interacting genomic region, meaning that DNA sequences within a TAD physically interact with each other more frequently than with sequences outside the TAD. [1] The median size of a TAD in mouse cells is 880 kb, and they have similar sizes in non-mammalian species. [2] WebCohesin also was shown to co-localize on chromosomes with a DNA binding protein called CTCF. CTCF is known to regulate transcription by forming DNA loops. Peters explains that, taken together, these observations hinted at a role for cohesin and CTCF in folding DNA into loops to allow efficient packing of very large eukaryotic genomes into small ... WebCTCF binding patterns, as measured by ChIP-exo in untreated CTCF-AID mESCs, were highly similar to untreated or 2-day treated wild-type (WT) untagged cells, highlighting that auxin treatment in itself does not affect overall CTCF binding, nor does tagging with the AID-eGFP cassette (Figure S2A). Using ChIP-seq in CTCF-AID cells after 2 days of ... free guy coming to hbomax