Hierarchical gatekeeping procedure
Web1 de jan. de 2024 · The graphical approach is a Bonferroni-based procedure. In general, gatekeeping procedures that are Bonferroni-based may have a corresponding graphical representation (entangled graphs [20] may be required for complicated procedures).For example, the basic parallel gatekeeping procedure using Bonferroni and the general … WebThis paper discusses multiple testing procedures in dose-response clinical trials with primary and secondary endpoints. A general gatekeeping framework for constructing multiple tests is proposed, which extends the Dunnett test [Journal of the American Statistical Association 1955; 50: 1096-1121] and Bonferroni-based gatekeeping tests …
Hierarchical gatekeeping procedure
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Web1 de nov. de 2015 · Gatekeeping procedures are designed to handle multiple hierarchical families of hypotheses. Before reviewing gatekeeping procedures, the fixed sequence … WebFirst, we give an overview of fundamental theories for multiple testing, such as partition testing and closed testing procedure. We then describe how gatekeeping strategies …
WebHochberg procedure (Xi & Bretz 2024) and several gatekeeping procedures (Dmitrienko et al. 2003, 2008, Li et al. 2024). However, controlling the FWER is a very stringent criterion, especially as the numberof hypotheses increases. By controlling the probability of even a single type I error, the power of FWER-controlling http://users.iems.northwestern.edu/~ajit/papers/40)%20Gatekeeping%20review07.pdf
http://users.iems.northwestern.edu/~ajit/papers/42)%20General%20Gatekeeping.pdf Web1 de jan. de 2006 · Related gatekeeping procedures addressing the problem of comparing several doses with a control for multiple hierarchical endpoints were described, among others, by Dmitrienko et al. (2006), Liu ...
WebThe parallel gatekeeping testing strategy provides an opportunity to assess secondary objectives when all or partial primary objectives are achieved. The current available gatekeeping procedure … Major objectives of a clinical trial are commonly stated in a hierarchical order as primary and secondary.
Web15 de jun. de 2011 · The proposed framework is based on combining multiple procedures across families and enables the construction of powerful and flexible gatekeeping procedures that account for general logical restrictions among the hypotheses of interest. This paper proposes a general framework for constructing gatekeeping procedures for … how to store arrowsWeb1 de jul. de 2007 · Statistics in medicine. 2007. TLDR. This paper discusses a new class of multiple testing procedures, tree-structured gatekeeping procedures, with clinical trial applications, based on the principle of closed testing and generalizes the serial and parallel gatekeeping approaches developed by Westfall and Krishen. 108. how to store articles in databaseWebIn a randomised clinical trial, when the result of the primary endpoint shows a significant benefit, the secondary endpoints are scrutinised to identify additional effects of the treatment. However, this approach entails a risk of concluding that there is a benefit for one of these endpoints when su … read the pdf file in pythonWebFigure 1: Graphical visualization of the gatekeeping procedure with truncated Holm procedure as gatekeeper. a truncated Holm procedure that is used for testing four … how to store aspirinWeb21 de jun. de 2007 · problem are known as gatekeeping procedures and have found a variety of applications in clinical trials. This paper reviews main classes of these … how to store artificial flower arrangementsWebUniversity of North Carolina at Chapel Hill read the peakWeb24 de fev. de 2006 · The proposed procedure accounts for the hierarchical structure of the testing problem; for example, it restricts testing of secondary endpoints to the doses for which the primary endpoint is significant. ... Gatekeeping procedures with clinical trial applications, Pharmaceutical Statistics, 10.1002/pst.291, 6, 3, ... how to store asparagus