WebBackground: Paclitaxel (PTX) has interesting anticancer activity. However, it is insoluble in water, which seriously hinders its use in clinical. Superparamagnetic iron oxide nanoparticles (SPIONs) are used as an ideal drug delivery system. Therefore, we proposed a folic acid (FA) targeting drug-loaded SPIONs to reduce its adverse reaction. WebNov 17, 2024 · The poor water solubility of paclitaxel causes significant problems in producing cancer therapeutic formulations. Here, we aimed to solubilize paclitaxel using …
A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor ...
WebMay 1, 2003 · The purpose of this study was to enhance the water-solubility of paclitaxel (PTX) using an amphiphilic 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer as … Web1 INTRODUCTION. Paclitaxel (PTX) is one of the most excellent chemotherapeutic drugs. It has been widely used in the first-line treatment of breast cancer [], ovarian cancer [], lung cancer [], and head and neck cancer [].However, poor solubility and lack of tumour cell selectivity are two major difficulties in the clinical application of PTX. fockea edulis 是什么
Determination of Free Concentration of Paclitaxel in Liposome …
Webspectrum of 0.1 mM paclitaxel in ethanol (100% soluble) was used as a standard for 100% incorporation in the lipid bilayer, and 0.1 mM paclitaxel in water (essentially 100% insoluble) was used as a standard for 0% incorporation in liposomes, respectively (Figure 1). Intermediate values of ellipticity, indicative of ‘‘partial incor- WebCitation 10–12 For instance, paclitaxel (PTX) has poor water solubility requiring the use of toxic excipients, Cremophor EL, in clinical formulations, which can cause severe … WebApr 10, 2024 · The major players in the Polymer Water-soluble Packages Market include : Lithey. Mondi Group. Sekisui Chemicals. Kuraray. Mitsubishi Chemical Holdings. Aicello Corporation. Aquapak Polymer. Lactips. fockea edulis from seed